General Information

The Institute for Clinical Endocrinology was founded in 1990. In the 1990–2001 it was headed by Evgeniya Marova — Honored Doctor of the Russian Federation, awarded with USSR State Prize, Doctor of Medical Sciences, Professor.

The Institute has accumulated unique experience in treating patients with rare (including orphan) endocrine diseases using the latest genetic, immunological and hormonal metabolic studies, modern ultrasonic and radiographic methods (densitometry, multislice computed tomography) and magnetic resonance imaging. Complex X-ray endovascular surgeries are carried out in the center allowing to localize pituitary neuroendocrine tumors and adrenal gland tumors.

All the departments of the Institute work according to the principles of multidisciplinary approach and continuity in diagnostics and treatment for each particular patient. If life-long follow-up is required, patients from the Institute for Pediatric Endocrinology are transferred to other departments of the Endocrinology research center.

The Institute has established and is actively implementing a medically and socially effective form of education and treatment in Obesity and Osteoporosis Schools.

Doctors of the Center’s three subdivisions cooperate in the Department of Reproductive Endocrinology: gynecological endocrinologists, andrologist-urologists and reproductive gynecologists. The department offers a wide range of services to provide highly qualified medical care (including both conservative and surgical treatment) to women and men suffering from various endocrine diseases resulting in reproductive disorders. The treatment also involves assisted reproductive technologies (ART), which allow for treatment not only of individual partners but also of couples.

Training programs on breast diseases, pregnancy planning and management, birth control, and menopausal specifics in women with endocrine pathology are developed and conducted monthly for healthcare professionals.

Structure of the Institute for Clinical Endocrinology:

• Department of Neuroendocrinology
• Department of Osteoporosis and Osteopathies
• Department of Parathyroid Glands Pathology and Disorders of mineral metabolism
• Department of Thyroid, Аdrenal Diseases and Obesity
• Department of Surgery

Diabetes mellitus today is a major hazard for humanity. A rapid increase in morbidity, incapacitation from an early age and high mortality rates account for the medical and social significance of the disease. Therefore, diabetes has a top priority for healthcare professionals around the world. It has resulted in passing a resolution on diabetes in 2006. The United Nations passed a resolution on diabetes in 2006. It was the fourth resolution to be adopted for particularly dangerous infections, as malaria, tuberculosis and HIV. However, long before that, on November 14, 1989, by Order No. 231 of the Director of the All-Union Endocrinology Research Center, USSR AMS, Professor Ivan Dedov, the Institute for Diabetes was established to improve the early diagnosis, prevention and treatment of diabetes mellitus in the Soviet Union.

At present the Institute for Diabetes is the base center in the Russian Federation to provide specialized and high-tech assistance to diabetes patients from the debut of the disease up to the terminal stages of vascular complications, as well as the reference center of the Ministry of Health and Social Development of the Russian Federation for development, testing and introduction of innovative technologies in diagnostics, prevention and treatment of diabetes mellitus and its complications. As well, it is the reference center of the Ministry of Health and Social Development of the Russian Federation for development, testing and introduction of innovative technologies in diagnosis, prevention and treatment of diabetes mellitus and its complications.

Advantages of treatment at the Institute for Diabetes:

The principle of systemic examination and treatment: all the necessary medical care is provided at one institution.

By visiting the Institute for Diabetes, the patient will receive comprehensive assistance from all specialists in the field of diabetology and related specialties: cardiology, nephrology, ophthalmology, gynecology, vascular surgery (stenting, angioplasty) and functional diagnostic methods. We do not treat the disease, but the patient.

Organs protection.

World-class technologies are introduced to prevent the development of vascular complications in diabetes (blindness, kidney failure, myocardial infarction, stroke, gangrene and lower limb amputation). The main aim of specialists is to offer the most effective methods of treatment with minimal traumatization — preservation and restoration of sight, prevention of limb amputations, maintenance of kidney function, restoration of blood flow in damaged vessels.

Observation — monitoring.

Patients have the opportunity to be monitored for life, receiving modern specialized medical care as both in- and out- patients.

The Institute for Diabetes is engaged in research in three main directions:

• Genome and post-genome technologies and nanotechnologies in the study of the mechanisms of development of diabetes mellitus and its complications.
• Molecular, genetic and hormonal-metabolic aspects of diagnosis, prevention, treatment and rehabilitation of patients with systemic vascular complications of diabetes mellitus.
• Prevention of diabetes mellitus, metabolic syndrome and obesity as socially significant diseases.

Structure of the Institute for Diabetes:

• Diabetic Kidney Disease and Post-Transplant Rehabilitation Department
• Diabetic Retinopathy and Ophthalmic Surgery Department
• Diabetic Foot Department
• Department of Cardiology and Vascular Surgery
• Department of Epidemiology and the State Register of Diabetes Mellitus
• Diabetes Prediction and Innovation Department
• Diabetes and Pregnancy Center
• Insulin Pump Therapy Center

The clinic of the Institute for Pediatric Endocrinology turned 50 years old in 2011. It is the first specialized clinic in Russia for diagnosis and treatment of endocrine diseases in children. At present, the most recent technologies are being developed and introduced into clinical practice using genomic markers and innovative methods of treatment based on the latest pharmacological achievements; methodological basics of the prognosis and prevention of endocrinopathies in children are being refined.

Key priorities of the Institute:

• Ensuring optimal physical and sexual development of children and adolescents in various diseases of the endocrine system.
• Creating National Registers of Endocrine Diseases
• Developing and implementing preventive programs aimed at reducing incidence and improving life quality of children with endocrine diseases
• Developing and implementing preventive programs aimed at reducing morbidity and improving life quality of children with endocrine diseases
• Developing methods of psychosocial adaptation of patients with different endocrine pathologies
• Genetic family counseling in the families of patients with various endocrine diseases

Admission Department:

Every year, the Institute for Pediatric Endocrinology conducts examination and treatment of 6-7 thousand children and adolescents by means of high-tech and specialized endocrinological care. 90% of them come from regions of the Russian Federation, 10% — from Moscow and non-CIS countries.

Medical care is provided in the in-patient and outpatient departments.

Scientific and methodological activities of the Institute:

The staff of the Institute consists of leading Russian specialists - professors, doctors and PhDs with extensive experience and knowledge in the field of the latest technologies for the diagnosis and treatment of endocrine diseases in children and adolescents. They work closely with pediatric endocrinologists from all regions of Russia, many of whom are co-authors of scientific studies, national registers and multi-center programs. The Institute for Pediatric Endocrinology also collaborates with leading foreign clinics and scientific centers. A number of educational activities are held as a part of post-graduate education and advanced training programs. Doctors undergo primary specialization and retraining in pediatric endocrinology. The Institute organizes the All-Russian and Regional Conferences on Pediatric Endocrinology. Specialists of the Institute carry out advisory assistance in the regions of the Russian Federation, give lectures and conduct seminars for guests of the Center-regional pediatric endocrinologists, publish articles in leading domestic and foreign journals, methodological guidelines, monographs.

The Alfa-Endo Program for Children with Endocrine Diseases contributes to improving the quality and accessibility of health care for children. The program is financed by Alpha-Group, implemented by the Foundation for Support and Development of Philanthropy "CAF" together with the Endocrinology research centre and the Charity Foundation "Life Line".

The program’s main fields of work:

• Molecular genetic diagnostics of childhood endocrinopathies
• Educational programs for specialists
• Introducing modern computer technologies in diabetology
• Patient Support Communities
• Preventing obesity in children

The curator of the program from the Endocrinology research centre is Valentina Peterkova — Director of the Institute for Pediatric Endocrinology, Deputy Director for Scientific Work, Chief external expert of Pediatric Endocrinology of the Ministry of Health of the Russian Federation, RAS Corresponding Member, Professor, Doctor of Medical Sciences.
The program’s webpage - http://alfa-endo.ru/

Structure of Institute for Pediatric Endocrinology:

• Pediatric Department of Diabetes Mellitus
• Department of Pediatric Thyroidology, Reproductive and Somatic Development
• Pediatric Department of Endocrine System Tumors
• Pediatric Surgery Department

The Institute for Oncoendocrinology is a multidisciplinary team, a community of specialists, ideas and technologies. It is radiomics, oncogenomics, radioguided surgery, biodosimetry, theranostics and other innovative areas of science and clinical practice.

The most significant advances in modern medicine arise at the intersection of sciences, such as molecular genetics and therapy, molecular imaging and surgery, dosimetry and radionuclide therapy. Achieving practical results in this area requires proactive multidisciplinary interaction of experts - holders of ideas, competencies and experience. Hybridization of technologies in radiology, for example, creates a favorable ground for interdisciplinary communication of radiologists, endocrinologists, oncologists and other doctors. However, without radiochemists and medical physicists, the professional symbiosis will not be complete and, as a result, successful. On the other hand, if a surgeon or therapist is not going to a molecular genetic and pathomorphological laboratory, they will miss out on finding like-minded professionals in lab workers and pathologists, respectively.

The Institute for Oncoendocrinology was founded in 2018 as part of the Endocrinology research centre in order to consolidate specialists of various profiles to improve prevention, diagnostics, treatment and rehabilitation of patients with endocrine and endocrine-dependent tumors.

At the moment the Institute of Oncoendocrinology is comprised of:

• Radionuclide Diagnostics Department
• Radionuclide Therapy Department
• Phoniatric Rehabilitation Office

In the future it is planned to create the following structural subdivisions:

• Intraoperative radio-guidance group
• Clinical dosimetry and theranostics group
• Laboratory of oncomorphology
• Laboratory of molecular oncoendocrinology
• Onco-biobank Laboratory
• Radiation Safety Service

Reproductive health is an area of medicine that traditionally focuses the attention of endocrinologists, obstetricians and gynecologists, pediatricians, neonatologists, urologists and andrologists, and that is beginning to attract the attention of doctors of other specialties. A decrease in fertility and, ultimately, infertility is a common problem: among married couples, every 7th couple is infertile. The decline in the birth rate in economically developed countries leads to population ageing and increases the financial burden on healthcare expenditures.

The problem of barren marriage goes far beyond the various fertility recovery technologies. A significant part of the reasons for the decline in fertility is formed in the prenatal period and early childhood and is potentially eliminated with timely preventive measures. Endocrine infertility inevitably entails a powerful trail of metabolic disorders, culminating in severe chronic diseases of the endocrine, cardiovascular and other systems and organs. In the elder age group, the focus of medical science is on the problems of menopause and a new issue – andropause. In medicine, the perennial issue of "men and women" has gained traction.

Time flies rapidly, and now humanity has a huge amount and variety of information on the reproductive health of men and women. Predictably, the revolutionary changes that have occurred in recent decades have resulted from an increase in the capabilities of diagnostic methods. Today, reproductive medicine has to take a step from the stage of simple accumulation of facts towards the introduction of the concept of evidence-based medicine and actually re-evaluate values.

The real challenge in terms of making use of the world scientific experience in Russia is that the principles of evidence-based medicine, widely applied in clinical practice by therapists and surgeons, have not yet taken a worthy place in reproductive medicine. Accordingly, the top priority of our work will be getting acquainted with the world trends in reproductive medicine and assessing the acceptability of the new knowledge in terms of evidence-based medicine. Accordingly, the top priority of our activity will be to get acquainted with the world trends of reproductive science and to assess the acceptability of the new knowledge in terms of evidence-based medicine. Criteria of acceptability are effectiveness and safety of diagnostic methods, validity of treatment methods.

In general, our task is to structure up-to-date scientific data, introduce them into practice make them as accessible as possible to a wide range of medical practitioners. Engaging various experts (endocrinologists, obstetrician gynecologists, pediatricians, andrologists, geneticists, epidemiologists, cardiologists, therapists, etc.) will lead to successful integration of their efforts in the treatment of diseases associated with a fertility reduction, and determine the most effective prevention and treatment strategy.

The Institute for Reproductive Medicine will help to find a solution to any reproductive problems and at any age - from disorders of sex development to diagnosis and treatment of infertility or treatment of climacteric disorders.

Continuity of medical care, timely prevention and correction of reproductive disorders will, hopefully, permit not only to solve problems but also to effectively prevent them in the future.

Main activities of the Institute for Reproductive Medicine:

• Monitoring the development of the reproductive system in children and adolescents
• Treatment of gendered pathology and sex development in children and adolescents
• Pregnancy planning
• Restoration of fertility in infertility couples
• Gynecological surgery
• Andrology and urological surgery
• Growth hormone deficiency: maintaining the quality of life

Structure of Institute for Reproductive Medicine:

• The office of complex diagnostics of diseases of the mammary glands
• Andrology and Urology Department
• Department of Assisted Reproductive Technologies
• Department of Endocrine Gynecology with a day hospital

Personalized medicine is a rapidly evolving field of healthcare, based on an integrated, coordinated and individual approach to the analysis of the onset and course of the disease for each patient. Medicine has always strived for personalization, but before deciphering the human genome, it was more a dream than a reality.

In 2017 the Institute for Personalized Medicine was established as a part of the Endocrinology research centre, based on personalized preventive care, risk prediction and targeted therapy.

The main approaches of personalized medicine include:

• Prediction of probability of disease based on genomic data;
• Transition from the traditional clinical to personalized diagnostics considering a patient’s individual characteristics;
• Selection of a treatment strategy according to individual characteristics of a patient;
• Pharmacological aspects, involving individual selection of medicines for a patient by combining genomic predictions and therapeutic drug monitoring.

Structure of the Institute for Personalized Medicine:

• Genomic research laboratory: gene panel sequencing by NGS method, such as «DM and Hyperinsulinism», «Congenital Hypothyroidism», «Rickets», «Hypopituitarism», «Hypogonadotropic Hypogonadism», «Familial Lipodystrophies», «Pituitary Adenomas», «Adrenal Insufficiency», «Fluid and Electrolyte Disorders», «Disorders of Sex Development», «Primary Hyperparathyroidism», «Primordial dwarfism», «Osteogenesis imperfecta»; whole exome sequencing; Sanger sequencing; Real-time PCR.
• Metabolome research laboratory: studying a range of steroid hormones by high performance liquid chromatography with tandem mass spectrometry (HPLS-MS/MS); analysis of priority estrogens in serum.
• Laboratory of Genetics of Monogenic Endocrine Diseases
• Fundamental Pathomorphology Department: morphological (cytological, histological) and immune morphological diagnostics of endocrine diseases. Along with the routine diagnostics, morphological express diagnostics is carried out using material obtained during FNA and surgical interventions.
• Laboratory of Cell Technologies: development of methods of diabetes mellitus therapy using technologies of reprogramming and genome editing; the study of molecular development mechanisms of multiple endocrine neoplasia; development of new approaches to gene therapy of inherited diseases.
• Bioinformatics Division: processing of primary data obtained by methods of high-performance sequencing (NGS); molecular-biological and clinical annotation of identified genetic variants; storage and recording the test results in our own database.
• Biobank: Creating biobanks along with patients’ registers is considered to be the main way to carry out translational research introducing fundamental knowledge into practical medicine. Currently, the biobank of blood plasma and DNA specimen is being created.
• Hereditary Childhood Endocrinopathies Department.

Structure of Institute for Personalized Medicine:

• Hereditary Childhood Endocrinopathies Department
• Laboratory of Genetics of Monogenic Endocrine Diseases
• Metabolome Research Laboratory
• Cell Technologies Laboratory
• Fundamental Pathomorphology Department

The Outpatient department of the Endocrinology research centre provides a full range of highly qualified advisory, diagnostic and therapeutic assistance to adults and children.

Admission of patients is carried out by various specialists, including candidates and doctors of medical sciences, physicians of the highest qualification category.

Outpatient department has the latest instrumental and technical equipment, including all types of ultrasound, laboratory, X-ray diagnostic devices.

Outpatient department of the Endocrinology research centre is the only specialized endocrinological advisory and diagnostic center in the country which allows to carry out diagnostics using innovative expert-class equipment in the shortest possible time, to establish an accurate diagnosis in a timely manner and prescribe the necessary treatment in time, approaching each patient individually.

Unique features of the Outpatient department:

• Highly professional and qualified medical staff with extensive experience
• Competence, responsibility, complete confidentiality, individual approach to each patient
• A wide range of healthcare services
• The best medical equipment of expert level from international manufacturers
• Availability of our own laboratory with the possibility of diagnostics in the shortest possible time
• Experience in the treatment of famous politicians, cultural and scientific personalities.

Structure of the Diagnostic and Advisory Center:

• Center for Treatment and Prevention of Metabolic Diseases and Obesity
• Endocrinopathies and Pregnancy Center
• Division of Epidemiology of Endocrinopathies
• Department of ultrasound diagnostics
• Department of personalized therapy of endocrinopathies
• Office of extracorporeal methods of renal pathology treatment
• Daycare hospital of general endocrinology
• Laboratories
• Reference Center for Pathomorphological Research
• Reception department
• Pediatric Reception Department
• Rehabilitation Department
• Office of aesthetic medicine
• Laboratory and production complex
• Administrative department
• Department of Coordination and Control of Medical Care for the Population
• Central Sterilization Department
• General Clinical Department
• Scientific and Organizational Department
• Press office