The Department of Personalized and Translational Medicine (PTMeD)
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The Department of Personalized and Translational Medicine (PTMeD) was founded in 2020 on the initiative of N.G. Mokrysheva, Corresponding Member of RAS, Director of the Endocrinology Research Institute of the Ministry of Health of the Russian Federation (hereinafter - ERC) as part of the Institute of Higher and Advanced Professional Education of the ERC and within the framework of the National Center for Personalized Medicine for Endocrine Diseases.
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OUR VISION
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The Center for Personalized Medicine for Endocrine Diseases, a world-class scientific facility based at the Endocrinology Research Center, has the mission to develop innovative technologies for personalized diagnosis and therapy of endocrine and onco-endocrine diseases and to create an analytical system for predicting the complications and outcomes of endocrine diseases.
These goals raise a demand for biological and medical researchers, as well as a high level of integration between clinical medicine and the biological science.
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Our task is to strengthen communication among scientists and to train researchers who are able to build a coherent scientific study plan from the clinical task through the laboratory to the result.
The ability to take such a comprehensive view requires interdisciplinary competence, an understanding of both the clinical features of the disease and the design and capabilities of a laboratory.
OUR TASKS
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Creation, management and implementation of educational programs in the field of the theoretical foundations of personalized medicine and translational medicine
Providing information on the latest scientific methodologies
Popularization of the latest scientific achievements in the field of personalized and translational medicine
Creation and implementation of educational programs on the diagnosis, treatment and monitoring of endocrine diseases from the perspective of personalized and translational medicine
Selecting and training the most qualified professionals for research work
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Personalized medicine is yet taking its first steps in real clinical routine. Cancer medicine is way ahead in implementing health practices that take the patient's specific genetic features into account. We are building a "bridge" between researchers (molecular biologists, bioinformaticians, clinical and laboratory geneticists) and clinicians by combining an understanding of modern scientific methods with the current needs of physician practice.
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Our priority is education focused on integrating clinical thinking into modern research.
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We take a comprehensive approach to providing knowledge about personalized and translational medicine. We see it as an investment in the human resources of the future through a variety of programs and internships for residents,
graduate students and physicians.
Our educational programs will provide students with the most up to date knowledge and help understand current scientific and clinical concepts.
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MAJOR FIELDS OF INTEREST
Creating and executing educational programs
Competitions
Internships at the laboratories of the ERC
Our staff members design and carry out educational programs that involve leading researchers and clinicians from Russia and around the world.
These programs pursue to improve the students' basic clinical competence and develop new fundamental theoretical knowledge in genetics, molecular biology, immunology, bioinformatics, cell technologies, and personalized pharmacology.
The World Level National Center (NCMU) offers remote learning opportunities with further training courses as part of their NCMU Grant package. The courses are available for residents, postgraduates, including foreign postgraduates, and physicians of various specialties. See link below for detailed instruction how to apply.
PROGRAMS AVAILABLE AS PART OF THE NCMU GRANT IN 2024:
- DRUG DESIGN AND REGULATION. GROWTH PROSPECTS FOR PHARMACOLOGY AND CLINICAL PHARMACOLOGY
This program is available free of charge as part of the NCMU Grant until the end of 2024. See the "How to enroll" PDF for details.This is a series of videos with supplementary files for self-study. At a time when medicine and technology are advancing rapidly, understanding how drugs are developed and overseen becomes a matter of the patient’s safety. This knowledge becomes even more important with the increasing number of innovative drugs which put special safety standards on manufacturing and use. Finally, understanding the production process for drugs opens up possibilities of a better dialogue with pharmacists and participation in clinical trials. The course will give you an idea about the drug development process, explain the succession and length of steps. This will have an immediate impact on the efficiency and safety of your treatment choices and follow-up activities on patients. - NEUROENDOCRINE REGULATION OF WATER-ELECTROLYTE METABOLISM. PERSONALIZED MANAGEMENT OF PATIENTS WITH WATER-ELECTROLYTE DISORDERS
This program is available free of charge as part of the NCMU Grant until the end of 2024. See the "How to enroll" PDF for details.This is a series of videos with supplementary files for self-study. Differential diagnosis of polyuric syndrome is a necessary competence of doctors of various specialties. The program covers the entire theory behind it and all practical skills a doctor needs to carry out diagnostics and treatment on patients with water-electrolyte disorders. You will better understand the physiology behind the synthesis and secretion of antidiuretic hormone, etiology and classification of different types of non-sugar diabetes; learn how to differentially diagnose polydipsia-polyuria syndrome, interpret results of functional tests (water deprivation test, desmopressin test) and adequately prescribe drug therapy.
THE "ENDOSPHERE" EDUCATIONAL SITE ALSO CONTAINS PAID PROGRAMS:
- PATHOGENESIS OF AUTOIMMUNE ENDOCRINE DISEASES AND INNOVATIVE APPROACHES THERAPY
The program contains lectures where immunology researchers talk about fundamentals of immune system design and the pathogenesis of autoimmune pathologies, and physicians and scientists discuss in detail endocrine system diseases and approaches to therapy. They will help students develop a holistic view of autoimmune pathologies. Among the diseases discussed are immune-mediated type 1 diabetes mellitus, primary hypothyroidism due to autoimmune thyroiditis, Graves' disease, autoimmune polyglandular syndromes, and autoimmune hypophysitis. A separate lecture talks about endocrine complications of therapy with immune response endpoint inhibitors. - MODERN APPROACHES TO DIAGNOSIS AND TREATMENT OF ONCOENDOCRINE DISEASES
This program outlines modern scientific view on oncoendocrinology with the help of leading biologists and doctors from the ERC. You will learn the latest developments in diagnosis, treatment and dynamic monitoring of thyroid cancer (P.Nikiforovich), perithyroid glands (Y.Krupinova), pheochromocytoma (D.Beltsevich), adrenocortical cancer (D.Beltsevich) and neuroendocrine tumors (O.Baranova).On top of that the program includes lectures on general issues of oncoendocrinology, such as pathomorphological and molecular genetic studies, as well as radionuclide diagnostics. Aspiring researchers may find interesting topics like "Translational research in oncology: from clinical issue to the laboratory" (by P.Nikiforovich), "Circulating nucleic acids, promising methods of early diagnosis" (by S.Popov), as well as an introduction to modern aspects of diagnosis and treatment of thyroid and perithyroid cancer. - DIAGNOSIS AND PERSONALIZED TREATMENT OF NODULAR NEOPLASMS OF THE THYROID GLAND
Nodular thyroid masses are one of the most common thyroid pathologies. They may be benign or malignant in effect. They are difficult for diagnostic search and choice of therapy to endocrinologists as well as doctors of other specialties. This course addresses the changes in the 5th edition of WHO (2022) pathomorphological classification of endocrine system tumors, modern conservative methods of treatment of thyroid malignancies, peculiarities of postoperative management by a team of doctors of different specialties. Streamlining diagnostic search and treatment plan is specially important for patients with nodular thyroid formations. This course covers the necessary theory and practical skill set which will enable a specialist to independently diagnose and treat nodular thyroid formations in their patient. - YOUNG SCIENTIST SCHOOL: MEDICAL STATISTICS. WHAT AN ASPIRING RESEARCHER NEEDS TO KNOW
There are many factors that affect the outcome of a biomedical study. These include the right definition of problems and the final purpose, competent data collection, choice of methods for statistical analysis and data processing. Knowing the basics of clinical epidemiology and statistical data processing will improve a researcher’s perspective and make them better at their work.The program covers aspects of research design and definition of scientific hypothesis, types of data, and the basics of database creation. Students will learn how to use descriptive statistics, ROC analysis, correlation analysis, multiple comparisons, calculation of relative risk and odds ratio. The goal is to improve their theory knowledge and practical skills in clinical epidemiology, statistical processing of medical data as well as the overall level within the existing specialty. The course is a series of videos along with practical tasks, project work and supplementaries for self-study. Enrolled students can ask questions to the responsible teacher along the way. The course ends with a test.
THE PERTRAM DEPARTMENT CARRIES ANNUAL COMPETITIONS FOR YOUNG RESEARCHERS AND SCIENCE PROJECTS.
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The Young Researcher Competition brings together specialists from all over Russia and CIS countries, engaged in scientific research in endocrinology and related fields. This Competition is an initiative of the ERC Director N.Mokrysheva. It is being held since 2022. The winners of are awarded additional points to apply for postgraduate education at the ERC, as well as memorable diplomas and valuable prizes.
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ON 23 APRIL 2024 TOOK PLACE THE YOUNG RESEARCHER COMPETITION" DEDICATED TO THE 100TH ANNIVERSARY OF THE ERC!
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39 works were filed from all over Russia (Chita, Chelyabinsk, Tula, Ufa, Tomsk, Saint-Petersburg), as well as from Uzbekistan’s capital city of Tashkent.
Our experts board selected 12 works for the oral session (6 original studies and 6 clinical cases) and 14 for online poster session (7 original studies and 7 clinical cases).
Read more about this even at the Endosphera website.
SCIENCE PROJECTS COMPETITION
The purpose of the Science Projects Competition is to encourage residents planning to enter the postgraduate program at the ERC to write a project of scientific work.
Participation is: writing an application (much like one for a grant) describing the relevance, objectives, goals, methods of the planned scientific work.
This competition was first held in 2023. The winner of the competition in 2023 is the work on "Predicting the risk of multi-organ complications in diabetic ketoacidosis with the help of neural network using molecular diagnostics of acute and chronic inflammation".
Applications for the Science Project Competition are accepted until May 20, 2024. Please fill out the form (rus) and send it to personalized.medicine [at] endocrincentr.ru.
In the years 2021–2023 internship programs for medical residents of the ERC took place in the laboratories for molecular genetics, pathomorphology and immunohistochemistry, metabolomics and proteomics, and cellular technologies. The selection process comes in two stages: a test in basic medicine and endocrinology, and writing scientific mini-reviews, which are then evaluated by experts. The rotation includes a course of classes on laboratory research methods, practical training, and eventually defense of a project work at the end. Students who successfully passed the “rotation” program in the laboratories get extra points towards their application for a postgraduate course at the ERC.
In 2024 we received 96 applications for the laboratory rotation. Only 20 interns passed the test and filed scientific review found good by our experts and were admitted onto the rotation: